Web Worker Daily has 7 Simple Ways to Improve Your Home Office.
The suggestions are fairly simple: you spend a lot of time and energy in this place, so you might as well make it pleasant and comfortable.
One advantage that we often have at home that officer workers may not have is natural lighting. If you’ve got windows, take advantage of them. They make a big difference in your mood. Of course, I do know some that prefer to work in the dim and dark, so I guess brick up your windows in that case. 😉 Either way, lighting makes a difference in your mood and productivity.
Another thing that helps me is being able to keep my office’s air comfortable. Now, I do have a lot of computers in here which generates a lot of heat. Consequently I have a portable A/C unit in my office because otherwise it’s a sweatshop, especially in the heat of the summer. But having your own A/C unit, fans, heaters, or whatever you need is useful so you can keep things where you like it. Wife likes it a bit warmer, loves to open up the windows (which often leads to higher humidity levels). I prefer it a bit cooler and drier.
It’s your office and being your home office you’ve got free reign over it. Take advantage of that to make your best workspace.